Stem cells of intestine epithelium. Survival mechanisms and microbiota role

   
Proskuryakov S.Ya.1 , Konoplyannikov A.G.2, Ulyanova L.P.1, Logunov D.Yu.2 , Narodicky B.S.2, Gincburg A.L.2

1. Medical Radiological Research Center Russian Academy of Medical Sciences
2. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences
Section: Review
PubMed Id: 20017391
Year: 2009  Volume: 55  Issue: 5  Pages: 587-609
The thanatogenetic mechanisms of stem cells (SC) of rapidly renewing system of intestinal epithelium still remain unclear. On the one hand, they are definitely involved into basic mechanisms of carcinogenesis in the gastrointestinal tract, because dysregulation of programs responsible for elimination of "unwanted" mutant cells (which are normally under immune and own intrinsic control) is one of the reasons of neoplastic expansion. On the other hand, elucidation and characterization of the regulatory machinery controlling SC survival are interrelated with problems of clinical medicine, including the increase of therapeutic efficiency of treatment of inflammatory and ulcer lesions of the gut, traumatic and surgical wounds, as well as restriction of side effects in normal tissues induced by application of intensive methods chemo- and radiotherapy of cancer. The latter is especially important for treatment of blood diseases and tumors of peritoneal cavity organs mainly due to bone marrow and intestinal epithelium damage. (These tissues are the most sensitive to these treatments.) The review considers data on exogenous and genetic modifiers of SC survival, and also the basic principles of mechanisms involved into renewal and regeneration of SC and the effects of microbiota on these processes.
Download PDF:  
Keywords: intestine epithelium, stem cells, crypt clonogenic cells, modifiers of destruction/survival rate, Wnt - β-catenin signaling pathway
Citation:

Proskuryakov, S. Ya., Konoplyannikov, A. G., Ulyanova, L. P., Logunov, D. Yu., Narodicky, B. S., Gincburg, A. L. (2009). Stem cells of intestine epithelium. Survival mechanisms and microbiota role. Biomeditsinskaya Khimiya, 55(5), 587-609.
This paper is also available as the English translation: 10.1134/S1990750809030020
References  
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)