Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia

   
Vishnevskii A.A.1 , Korotkevich I.G.1, Zhanayeva G.A.1, Zhaparalieva Ch.O.1

1. Institute of Mountain Physiology, National Academy of Kyrgyzstan
Section: Experimental/Clinical Study
UDK: 615.357.03:613.863].015.4.076.9      PubMed Id: 20017394
Year: 2009  Volume: 55  Issue: 5  Pages: 635-642
The membrane, antioxidant and functional effects of vinpocetine and α-tocopherol have been investigated under conditions of acute experimental cerebral ischemia in rats. Vinpocetine administration decreased accumulation of lysophospholipids in brain plasma membranes. Vinpocetine also blocked accumulation of conjugated dienes (CD). α-Tocopherol inhibited augmentation in CD content and did not reduce the level of lysophospholipids in brain plasma membranes. Functional consequences of membrane impairments were also detected in some behavioral tests and physical capabilities. Administration of both vinpocetine and α-tocopherol decreased manifestations of the altered parameters induced by cerebral ischemia and vinpocetine was more effective than α-tocopherol.
Download PDF:
Reference:

Vishnevskii A.A., Korotkevich I.G., Zhanayeva G.A., Zhaparalieva Ch.O. (2009) Biomeditsinskaya khimiya, 55(5), 635-642.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)
        

© Institute of Biomedical Chemistry, Moscow, Russia