The influense of guanidine derivatives on free radical oxidation intensity and aconitase activity at development of brain ischemia-reperfusion at rats

Makeeva А.V.1 , Popova T.N.1, Slivkin A.I.2, Krylsky D.V.2

1. Department of Medical Biochemistry and Microbiology, Biology and Soil Science Faculty, Voronezh State University
2. Department of Pharmaceutical Chemistry and Technology, Pharmaceutical Faculty, Voronezh State University
Section: Experimental/Clinical Study
UDK: 577.334:616.831:577.112.3      PubMed Id: 20017395
Year: 2009  Volume: 55  Issue: 5  Pages: 643-650
The study of some guanidine derivatives influence on free radical oxidation intensity and aconitase activity during the development of brain ischemia-reperfusion at rats has been carried out. The biochemiluminescence parameters increasing at the brain pathology changed toward normal values under the influence of N-[4-(chlorbenzoyl)benztiazol-2-yl]guanidine, N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine. The aconitase specific activity decreased in brain and blood of animals with ischemia-reperfusion. Administration of guanidine derivatives during brain ischemia-reperfusion development increased aconitase specific activity. These results suggest that investigated substances can play a role of neuroprotectors, preventing free radical oxidation development.
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Makeeva А.V., Popova T.N., Slivkin A.I., Krylsky D.V. (2009) Biomeditsinskaya khimiya, 55(5), 643-650.
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