The effect of Thapsigargicin (TGC), a non-phorbol ester type tumor promoter, on Ca2+ movements has been investigated using L1210 mouse lymphoma cells. Ca2+ release from intact and digitonin permeabilized cells was evaluated using Fura-2 and Fura-3. TGC like Thapsigargin (TG) has the ability to discharge the intracellular Ca2+ stores and to increase intracellular free Ca2+ concentrations. TGC in a concentration dependent manner (0.16-16 nM) also inhibited cell growth and this effect was at least partially reversed by arachidonate.
Oztetik E. (2009) Effects of thapsigargicin on Cа2+ movements in L1210 cells permeabilized with digitonin. Biomeditsinskaya Khimiya, 55(5), 651-662.
et al. Effects of thapsigargicin on Cа2+ movements in L1210 cells permeabilized with digitonin // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 5. - P. 651-662.
et al., "Effects of thapsigargicin on Cа2+ movements in L1210 cells permeabilized with digitonin." Biomeditsinskaya Khimiya 55.5 (2009): 651-662.
Oztetik, E. (2009). Effects of thapsigargicin on Cа2+ movements in L1210 cells permeabilized with digitonin. Biomeditsinskaya Khimiya, 55(5), 651-662.
