Essential edema-proteinuria-hypertension (EPH) gestosis still represents an important obstetrical problem. We have investigated the activity of carboxypeptidase Н (CPН), phenylmethylsulfonyl fluoride inhibited carboxypeptidase (PMSF-CP), carboxypeptidase M (CPM) and angiotensin-converting enzyme (ACE), the main carboxypeptidases in human placenta under normal conditions and mild EPH-gestosis. Gestosis was accompanied by the decrease in activity of the enzymes involved into metabolism of regulatory peptides (ACE, CPH, PMSF-CP, CPM) compared with their activity in placenta under physiological pregnancy. Correlation analysis revealed positive correlation between placental CPH and CPM (r = 0.2735*) in EPH-gestosis. These findings suggest involvement of placental proteases into formation of compensatory-adaptive reactions in the fetoplacental complex at EPH-gestosis; the data obtained may be also employed for the development of methods of prophylaxis and corrections of metabolic impairments in pathology of pregnancy.
Petrushova O.P., Gengin M.T., Smetanin V.A., Kuznetsova A.V. (2009) Proteolytic activity of placenta with EPH-gestosis. Biomeditsinskaya Khimiya, 55(5), 673-680.
Petrushova O.P. et al. Proteolytic activity of placenta with EPH-gestosis // Biomeditsinskaya Khimiya. - 2009. - V. 55. -N 5. - P. 673-680.
Petrushova O.P. et al., "Proteolytic activity of placenta with EPH-gestosis." Biomeditsinskaya Khimiya 55.5 (2009): 673-680.
Petrushova, O. P., Gengin, M. T., Smetanin, V. A., Kuznetsova, A. V. (2009). Proteolytic activity of placenta with EPH-gestosis. Biomeditsinskaya Khimiya, 55(5), 673-680.
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