A comparative study of biodegradation kinetics of biopolymer systems based on poly(3-hydroxybutyrate)

Boskhomdzhiev A.P.1 , Bonartsev A.P.1, Makhina T.K.1, Myshkina V.L.1, Ivanov E.A.1, Bagrov D.V.2, Filatova E.V.1, Iordanskii A.L.1, Bonartseva G.A.1

1. A.N. Bach Institute of Biochemistry, Russian Academy of Sciences
2. Faculty of Biology, M.V. Lomonosov Moscow State University
Section: Experimental/Clinical Study
PubMed Id: 20469718
Year: 2009  Volume: 55  Issue: 6  Pages: 702-712
The aim of this study was to evaluate and to compare of long-term kinetics curves of biodegradation of poly(3-hydroxybutyrate) (PHB), its copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and PHB/polylactic acid blend. The total weight loss and the change of average viscosity molecular weight were used as an index of biodegradation degree. The rate of biodegradation was analyzed in vitro in presence of lipase and in vivo when the films were implanted in animal tissues. The morphology of PHB films surface was studied by atomic force microscopy technique. It was shown that biodegradation of PHB is occurred by means of as polymer hydrolysis, and as its enzymatic biodegradation. The obtained data can be used for development of medical devices on the base of PHB.
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Keywords: polyhydroxyalkanoates (PHA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polylactic acid (PLA), biodegradation, biopolymer system

Boskhomdzhiev, A. P., Bonartsev, A. P., Makhina, T. K., Myshkina, V. L., Ivanov, E. A., Bagrov, D. V., Filatova, E. V., Iordanskii, A. L., Bonartseva, G. A. (2009). A comparative study of biodegradation kinetics of biopolymer systems based on poly(3-hydroxybutyrate). Biomeditsinskaya Khimiya, 55(6), 702-712.
This paper is also available as the English translation: 10.1134/S1990750810020083
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