Phosphorylation of ATM/ATR substrates in eukaryotic cells after infection with helicobacter pylori

   
Anikeenok M.O.1 , Churin Y.N.2, Meyer T.F.2, Ilinskaya O.N.1

1. Kazan State University, Department of microbiology
2. Department of Molecular Biology, Max Planck Institute for Infection Biology
Section: Experimental/Clinical Study
PubMed Id: 20469721
Year: 2009  Volume: 55  Issue: 6  Pages: 734-742
Infection with Helicobacter pylori has been associated with the development of gastric adenocarcinoma in humans, but influence on genetic material of the host cell is still unknown. Here we characterize phosphorylation of ATM-kinase substrates in HeLa and AGS cells in response of Helicobacter pylori attack. Infection with wild-type (cag PAI-positive) and corresponding isogenic cag PAI negative mutant induces activation of Chk1 and Chk2 kinases. Only Chk1 is activated directly by ATM-kinase. We identified group of proteins which are activated by the Helicobacter pylori in AGS cells, using MALDI analyze and two-dimentional gel electrophoresis.
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Keywords: Helicobacter pylori, ATM/ATP kinases, phosphorylation, RPA32A, splicing-factor
Citation:

Anikeenok, M. O., Churin, Y. N., Meyer, T. F., Ilinskaya, O. N. (2009). Phosphorylation of ATM/ATR substrates in eukaryotic cells after infection with helicobacter pylori. Biomeditsinskaya khimiya, 55(6), 734-742.
This paper is also available as the English translation: 10.1134/S1990750810020071
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