Cardioprotective effect of n-stearoylethanolamine under the anaphylactic shoсk in guinea pigs

   
Hula N.M.1 , Berdyshev A.H.1, Chumak A.A.1, Kindruk N.L.1, Goridko T.M.1

1. Palladin Institute of Biochemistry of National Academy of Science of Ukraine
Section: Experimental/Clinical Study
PubMed Id: 20469722
Year: 2009  Volume: 55  Issue: 6  Pages: 743-749
It was shown for the first time that endogenous cannabimimetic compound N-stearoylethanolamine (NSE) administered at the dose 65 mg/kg of body weight during two weeks before anaphylaxis had cardioprotective properties on the model of anaphylactic shock in the guinea pigs. NSE reliably normalized the content of histamine and nitric oxide, decreased the activity both inducible and constitutive NO-synthases, prevented accumulation of thiobarbituric acid reactive substances (TBARS) and normalized the activity of catalase, superoxide dismutase and glutathione peroxidase in cardiomyocytes of animals under anaphylaxis. About of 70% of the NSE-treated animals survived under the anaphylactic shock. The present work indicates that NSE may influence the allergic reaction of immediate type and can possibly be used for design of a new type of antiallergic preparations and cardioprotective preparations as well.
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Keywords: N-stearoylethanolamine, anaphylaxis, histamine, nitric oxide, lipids peroxidation
Citation:

Hula, N. M., Berdyshev, A. H., Chumak, A. A., Kindruk, N. L., Goridko, T. M. (2009). Cardioprotective effect of n-stearoylethanolamine under the anaphylactic shoсk in guinea pigs. Biomeditsinskaya khimiya, 55(6), 743-749.
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