Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia

   
Moshkova A.N.1 , Yerlykina E.I.2 , Khvatova E.M.2

1. Nizhnii Novgorod State Technical University
2. Nizhnii Novgorod State Academy of Medicine
Section: Experimental/Clinical Study
PubMed Id: 20469724
Year: 2009  Volume: 55  Issue: 6  Pages: 759-765
The disturbances of blood circulation changes metabolism and energy reactions in the brain. The method of mathematical analysis is used for the study of the dependence between the activity mitochondrial creatine kinase (CK) and ATP level the brains of rats subjected to acute and chronic ischemia. A model describing this dependence under different conditions of the activity of organisms has been proposed. Thus it is possible to predict catalytic properties of CK based on ATP level.
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Keywords: creatine kinase, ATP, brain, ischemia, function
Citation:

Moshkova, A. N., Yerlykina, E. I., Khvatova, E. M. (2009). Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia. Biomeditsinskaya khimiya, 55(6), 759-765.
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