The disturbances of blood circulation changes metabolism and energy reactions in the brain. The method of mathematical analysis is used for the study of the dependence between the activity mitochondrial creatine kinase (CK) and ATP level the brains of rats subjected to acute and chronic ischemia. A model describing this dependence under different conditions of the activity of organisms has been proposed. Thus it is possible to predict catalytic properties of CK based on ATP level.
Keywords: creatine kinase, ATP, brain, ischemia, function