Effect of complexes of precursors and modulators of coenzyme q biosynthesis on functional state of old rats' heart mitochondria

   
Kuchmenko E.B.1 , Petukhov D.N.1, Donchenko G.V.1, Mkhitaryan L.S.2 , Tymoshchuk S.V.3 , Strutynskaya N.A.3, Vavilova G.L.3, Sagach V.F.3

1. Palladin Institute of Biochemistry of NAS of Ukraine
2. National Scientific Center "Strazhesko Institute of Cardiology" of AMS of Ukraine
3. Bogomoletz Insitute of Physiology of NAS of Ukraine
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20105602244      PubMed Id: 21341512
Year: 2010  Volume: 56  Issue: 2  Pages: 244-256
Our research demonstrate that ageing leads to changes in activity of electron-transporting enzyme complexes in myocardial mitochondria of old rats and to increased sensitivity of mitochondrial permeability transition pore to inductors of its opening - Ca2+ and phenylarsine oxide. We also observed activation of lipid and protein free-radical peroxidation processes. Administration of a complex of biologically active substances that included precursors and modulators of coenzyme Q biosynthesis (α-tocopherol acetate, 4-hydroxybenzoic acid, and methionine) we observed the increase in coenzyme Q content, correction of functional activity of mitochondrial electron-transport chain enzyme complexes, the decrease in intensivity of lipid and protein free-radical peroxidation in the heart and the decrease in sensitivity of mitochondrial permeability transition pore to inductors of its opening. This complex may be used to treat mitochondrial dysfunction under numerous pathologies of cardiovascular system, as well as in ageing.
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Keywords: coenzyme Q (ubiquinone), old animals, lipid and protein free-radical peroxidation, mitochondrial permeability transition pore
Citation:

Kuchmenko, E. B., Petukhov, D. N., Donchenko, G. V., Mkhitaryan, L. S., Tymoshchuk, S. V., Strutynskaya, N. A., Vavilova, G. L., Sagach, V. F. (2010). Effect of complexes of precursors and modulators of coenzyme q biosynthesis on functional state of old rats' heart mitochondria. Biomeditsinskaya Khimiya, 56(2), 244-256.
This paper is also available as the English translation: 10.1134/S199075080904009X
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