Cathepsin K and matrix metalloproteases activity in bone tissue of OXYS rats with osteoporosis development

Venediktova A.A.1 , Falameeva O.V.2, Kolosova N.G.3, Sadovoj M.A.2, Korolenko T.A.1

1. Institute of Physiology, Sibirian Branch, Russian Academy of Medical Scinences
2. Federal State Research Institute of Traumatology and Orthopedics, Federal Agency of Medical High Technology Assistance
3. Institute of Cytology and Genetics, Sibirian Branch, Russian Academy of Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20105602274      PubMed Id: 21341515
Year: 2010  Volume: 56  Issue: 2  Pages: 274-282
The comparative study of аctivity of cysteine protease cathepsin K and matrix metalloproteases (MMPs) in bone tissue of accelerated senescent OXYS rats with early ageing comparatively to Wistar rats of the same age was performed. Early development osteoporosis is a typical feature of OXYS rats. In bone tissue of 3 month old OXYS rats, before appearance of osteoporosis manifestation cathepsin K activity was higher, whereas MMPs activity was lower than in Wistar rats. In Wistar rats (3 and 14 months old) cathepsin K activity of spine was shown to increase, and MMPs activity to decrease. In OXYS rats age-related change of cathepsin K and MMPs activity in bone tissue had the opposite direction. As a result of this there were no differences between Wistar and OXYS rats 14 months old despite the marked osteoporosis in OXYS rats as revealed our early researches. Serum α2-macroglobulin activity was higher in 14 months old OXYS rats. The role of activation of cathepsin K in bone resorption in the development of osteoporosis in early ageing OXYS rats is discussed.
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Keywords: cathepsin K, matrix metalloproteases, bone resorption, early ageing OXYS rats, osteoporosis irreversibility

Venediktova, A. A., Falameeva, O. V., Kolosova, N. G., Sadovoj, M. A., Korolenko, T. A. (2010). Cathepsin K and matrix metalloproteases activity in bone tissue of OXYS rats with osteoporosis development. Biomeditsinskaya Khimiya, 56(2), 274-282.
This paper is also available as the English translation: 10.1134/S1990750809040106
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