Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats

   
Shpakov A.O.1 , Shpakova E.A.1

1. I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Section: Review
DOI: 10.18097/pbmc20105603303      UDK: 577.17      PubMed Id: 20695210
Year: 2010  Volume: 56  Issue: 3  Pages: 303-318
During the last years the low-molecular non-peptidic regulators of the polypeptide hormones receptors containing LGR-repeats were identified. In the review the data on the structure and the molecular mechanisms of action of these regulators as agonists and antagonists of the luteinizing, follicle-stimulating and thyrotropin hormones are analyzed and systematized. The regulators interact with the serpentine domain of LGR-receptor and trigger the signaling cascades coupled with the receptor. Low-molecular agonists and antagonists of the LGR-receptors are considered as a new generation of the drugs that regulates the functional activity of sensitive to pituitary glycoprotein hormones signaling systems with high efficiency and selectivity. These regulators are more accessible compared to the hormones and can be use orally.
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Shpakov A.O., Shpakova E.A. (2010) Biomeditsinskaya khimiya, 56(3), 303-318.
This paper is also available as the English translation:10.1134/S1990750809040040
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