During the last years the low-molecular non-peptidic regulators of the polypeptide hormones receptors containing LGR-repeats were identified. In the review the data on the structure and the molecular mechanisms of action of these regulators as agonists and antagonists of the luteinizing, follicle-stimulating and thyrotropin hormones are analyzed and systematized. The regulators interact with the serpentine domain of LGR-receptor and trigger the signaling cascades coupled with the receptor. Low-molecular agonists and antagonists of the LGR-receptors are considered as a new generation of the drugs that regulates the functional activity of sensitive to pituitary glycoprotein hormones signaling systems with high efficiency and selectivity. These regulators are more accessible compared to the hormones and can be use orally.
Shpakov A.O. et al. Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats // Biomeditsinskaya Khimiya. - 2010. - V. 56. -N 3. - P. 303-318.
Shpakov A.O. et al., "Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats." Biomeditsinskaya Khimiya 56.3 (2010): 303-318.
Shpakov, A. O., Shpakova, E. A. (2010). Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats. Biomeditsinskaya Khimiya, 56(3), 303-318.
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