The antioxidant status at patients with a thyreotoxicosis syndrome at the combined therapy with epifamin

Popov S.S.1, Pashkov A.N.1, Zoloedov V.I.1, Popova T.N.2 , Rakhmanova T.I.2

1. Voronezh State Medical Academy of N.N. Burdenko
2. Voronezh State University
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20105603397      UDK: 577.17:615.036      PubMed Id: 20695219
Year: 2010  Volume: 56  Issue: 3  Pages: 397-403
The work purpose was research of degree of free-radical processes intensity and catalase activity in blood serum of patients with a thyreotoxicosis syndrome at traditional treatment and the combined therapy with epifamin. Patients (n=25) have been divided into 2 groups: the first group of patients - 12 persons who are on traditional treatment (antithyreoid drugs, β-adrenoblockers); the second group - 13 persons, are padding to basic therapy received epifamin on 1 tablet (10 mg) 3 times a day 10-15 minutes prior to meal within 7 days. Patients with thyreotoxicosis syndrome had an intensification of free-radical oxidation that was traced at measurement of biochemiluminescence parameters in blood serum. At the combined therapy with epifamin less expressed intensity of free-radical processes, and also increasing of the general antioxidant activity of an organism that did not descend at traditional treatment was observed. At carrying out of standard therapy of thyreotoxicosis syndrome, including application of antithyreoid drugs and β-adrenoblockers, catalase activity decreased, that unfavorable affected antioxidant potential of an organism. At the combined therapy with epifamin level of catalase activity, on the contrary, increased, that could influence positively on antioxidant protection of an organism.
Download PDF:

Popov S.S., Pashkov A.N., Zoloedov V.I., Popova T.N., Rakhmanova T.I. (2010) Biomeditsinskaya khimiya, 56(3), 397-403.
This paper is also available as the English translation:10.1134/S199075081004013X
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)

© Institute of Biomedical Chemistry, Moscow, Russia