Glycerolipids of alkyl type - modulators of tumoral cells destruction

   
Romanova S.G.1 , Romanov V.G.1 , Serebrennikova G.A.1 , Shtil A.A.2

1. Lomonosov Moscow State Academy of Fine Chemical Technology
2. Blokhin Oncological Research Center, Russian Academy of Medical Sciences
Section: Review
DOI: 10.18097/pbmc20105604457      PubMed Id: 21032896
Year: 2010  Volume: 56  Issue: 4  Pages: 457-470
The review is summarizes current information on biological activity and search of the antineoplastic mechanism of action of alkyl glycerolipids. Special attention is paid to following problems: selective ability phosphorus alkyl glycerolipids, antineoplastic activity, cytostatic and cytotoxic effects of edelfosine and its analogues. The review contains set of the data known for today from the literature, on the possible mechanism cytoyoxic actions of such connections.
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Keywords: alkyl glycerolipids, edelfosine, anticancer activity, apoptosis
Citation:

Romanova, S. G., Romanov, V. G., Serebrennikova, G. A., Shtil, A. A. (2010). Glycerolipids of alkyl type - modulators of tumoral cells destruction. Biomeditsinskaya khimiya, 56(4), 457-470.
This paper is also available as the English translation: 10.1134/S199075081002006X
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