Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features of high- and low-effective anti-arrhythmic agents have been recognized and the influence of these features on the anti-arrhythmic properties has been evaluated. This information has been used for generation of the model for prediction of anti-arrhythmic effectiveness of pharmaceutical preparations with the 82%-level of recognition by two methods. The recognized structural parameters may be successfully used for design of new highly effective anti-arrhythmic drugs, and also for modification of structures of known anti-arrhythmic drugs for the increase of effectiveness of their anti-arrhythmic action.
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Keywords: structure-activity, anti-arrhythmic activity, theory of shape recognition
Citation:
Khairullina V.R., Tarasov G.P., Gerchikov A.Ja., Zarydiy F.S., Tjurina L.A. (2010) Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids. Biomeditsinskaya Khimiya, 56(4), 471-479.
Khairullina V.R. et al. Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids // Biomeditsinskaya Khimiya. - 2010. - V. 56. -N 4. - P. 471-479.
Khairullina V.R. et al., "Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids." Biomeditsinskaya Khimiya 56.4 (2010): 471-479.
Khairullina, V. R., Tarasov, G. P., Gerchikov, A. Ja., Zarydiy, F. S., Tjurina, L. A. (2010). Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids. Biomeditsinskaya Khimiya, 56(4), 471-479.
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