Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids

   
Khairullina V.R.1 , Tarasov G.P.1 , Gerchikov A.Ja.1 , Zarydiy F.S.2 , Tjurina L.A.2

1. Bashkir State University
2. Institute of Organic Chemistry, Ufa Scientific Center of Russian Academy of Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20105604471      PubMed Id: 21032897
Year: 2010  Volume: 56  Issue: 4  Pages: 471-479
Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features of high- and low-effective anti-arrhythmic agents have been recognized and the influence of these features on the anti-arrhythmic properties has been evaluated. This information has been used for generation of the model for prediction of anti-arrhythmic effectiveness of pharmaceutical preparations with the 82%-level of recognition by two methods. The recognized structural parameters may be successfully used for design of new highly effective anti-arrhythmic drugs, and also for modification of structures of known anti-arrhythmic drugs for the increase of effectiveness of their anti-arrhythmic action.
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Keywords: structure-activity, anti-arrhythmic activity, theory of shape recognition
Citation:

Khairullina, V. R., Tarasov, G. P., Gerchikov, A. Ja., Zarydiy, F. S., Tjurina, L. A. (2010). Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids. Biomeditsinskaya khimiya, 56(4), 471-479.
This paper is also available as the English translation: 10.1134/S1990750810020034
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