Lipid peroxidation, activity of Na+,K+-ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride

   
Tedtoeva A.I.1 , Dzugkoeva F.S.1 , Mozhaeva I.V.1 , Dzugkoev S.G.1

1. Institute of Biomedical Studies, Vladikavkaz Scientific Center, Russian Academy of Science and Government of Republic Northern Osetia Alania
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20105605540      PubMed Id: 21254623
Year: 2010  Volume: 56  Issue: 5  Pages: 540-544
Chronic parenteral administration of cobalt chloride (6 mg/kg) to male rats for 2 weeks or 1 month was accompanied by activation of lipid peroxidation (LPO), a decrease of superoxide dismutase activity and an increase of catalase activity. The membrane toxic action also resulted in a decrease of cortical and medullar Na+,K+-ATPase activity of kidneys, and the decrease in renal functions (glomerular filtration, renal water reabsorption, spontaneous diuresis, electrolyte excretion).
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Keywords: cobalt, lipid peroxidation, superoxide dismutase, catalase, kidney, cell antioxidant defense
Citation:

Tedtoeva, A. I., Dzugkoeva, F. S., Mozhaeva, I. V., Dzugkoev, S. G. (2010). Lipid peroxidation, activity of Na+,K+-ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride. Biomeditsinskaya khimiya, 56(5), 540-544.
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