L-Cysteine Influx in Type 2 Diabetic Erythrocytes
Rizvi S.I.1 , Srivastava N.1 1. University of Allahabad Section: Experimental/Clinical Study DOI: 10.18097/PBMC20105605545 PubMed Id: 21254624
Year: 2010 Volume: 56 Issue : 5 Pages: 545-551 Erythrocyte oxidative stress has been implicated in the pathogenesis of diabetes mellitus, and the deficiency of antioxidant defense by the glutathione (GSH) pathway is thought to be one of the factors responsible for development of complications in diabetes. Erythrocytes require L-cysteine for the synthesis of GSH and the rate of synthesis is determined only by L-cysteine availability. In the present study we have found that the L-cysteine influx in erythrocytes from type 2 diabetic patients was significantly lower compared to age-matched controls. The decreased influx may be one of the factors leading to low GSH concentration observed in type 2 diabetes. Since L-cysteine is the limiting amino acid in GSH synthesis, any strategy aimed to increase L-cysteine influx in erythrocytes may be beneficial for type 2 diabetic patients.Download PDF: Keywords: erythrocytes, L-cysteine, diabetes mellitus
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Rizvi S.I., Srivastava N. (2010) L-Cysteine Influx in Type 2 Diabetic Erythrocytes. Biomeditsinskaya Khimiya, 56 (5), 545-551.
Rizvi S.I. et al. L-Cysteine Influx in Type 2 Diabetic Erythrocytes // Biomeditsinskaya Khimiya. - 2010. - V. 56. -N 5. - P. 545-551.
Rizvi S.I. et al., "L-Cysteine Influx in Type 2 Diabetic Erythrocytes." Biomeditsinskaya Khimiya 56.5 (2010): 545-551.
Rizvi, S. I., Srivastava, N. (2010). L-Cysteine Influx in Type 2 Diabetic Erythrocytes. Biomeditsinskaya Khimiya , 56(5), 545-551.
This paper is also available as the English translation: 10.1134/S1990750810020125
References Show
Halliwell B., Gutteridge J.M.C. (1986) Arch. Biochem. Biophys., 246, 501-514. CrossRef Scholar google search Maridonneau I., Barquet P., Garay R.P. (1983) J. Biol. Chem, 258, 3107-3113. Scholar google search Rohan T.T., Nelson L.K., Waeg G., Quinn M.T. (1998) Biochem. Pharmacol, 56, 1371-1379. CrossRef Scholar google search Snyder L.M., Fortier N.L., Leb L., McKenney J., Trainor J., Sheerin H., Mohandas N. (1988) Biochim. Biophys. Acta., 937, 229-240. CrossRef Scholar google search Cakatay U., Kayali R., Erdogan C., Orhan Y., Sivas A., Akcay T. (2000) Horm. Metab. Res, 32, 40-43. CrossRef Scholar google search Davies K.J.A., Goldberg A.L. (1987) J. Biol. Chem, 262, 8220-8226. Scholar google search Bryszewska M., Zavodnik I.B., Niekurzak A., Szosland K. (1995) Biochem. Mol. Biol. Int., 37, 345-354. Scholar google search Saltsburg H., Katter Y., Aviary M., Levy Y. (1999) Isr. Med. Assoc. J., 1, 228-231. Scholar google search Vijayalingam S., Parthiban A., Shanmugasundaram K.R., Mohan V. (1996) Diabet. Med., 13, 715-719. CrossRef Scholar google search Maritim A., Sanders R., Watkins J. (2003) J. Biochem. Mol. Toxicol., 17, 24-38. CrossRef Scholar google search Nwose E.U., Jelinek H.F., Richards R.S., Kerr P.G. (2007) Br. J. Biomedical. Sci., 64, 35-43. Scholar google search Dincer Y., Akcay T., Alademir Z., Ilkova H. (2002) Metabolism, 51, 1360. CrossRef Scholar google search Rizvi S.I., Zaid M.A., Anis R., Mishra N. (2005) Clin. Exp. Pharmacol. Physiol., 32, 70-75. CrossRef Scholar google search Nwose E.U., Jelinek H.F., Richards R.S., Kerr P.G. (2006) Redox Rep., 11, 99-104. CrossRef Scholar google search Yildiz D., Uslu C., Cakir Y., Oztas H. (2006) Free Radic. Res., 40, 507-512. CrossRef Scholar google search Griffith O.W. (1992) Free Radic. Biol. Med., 27, 922-935. CrossRef Scholar google search Rizvi S.I., Zaid M.A. (2005) Clin. Chim. Acta, 354, 59-67. CrossRef Scholar google search Rizvi S.I., Maurya P.K. (2008) Rejuvination Research, 11, 661-665. CrossRef Scholar google search Sedlak J., Lindsay R.H. (1963) Anal. Biochem., 25, 192-205. CrossRef Scholar google search Benzie I.F.F., Strain J.J. (1996) Anal Biochem., 239, 70-76. CrossRef Scholar google search Beutler E., Duron O., Durate B.M.K. (1963) J. Lab.Clin. Med, 51, 882-888. Scholar google search Rizvi S.I., Abu Zaid M. (2001) J. Physiol. Pharmacol., 52, 483-488. Scholar google search Dincer Y., Alademir Z., Iikova H., Akcay T. (2002) Clin. Biochem, 35, 297-301. CrossRef Scholar google search Coleman M.D., Rustiom C.V. (1999) J. Pharm. Pharmacol., 51, 21-25. CrossRef Scholar google search Breitkreutz R., Pittack N., Nebe C.T., Schuster D., Brust J., Beichert M., Hack V., Daniel V., Edler L., Droge W. (2000) J. Mol. Med., 78, 55-62. CrossRef Scholar google search Sen C.K., Packer L. (2000) Am. J. Clin. Nutr., 72, 653S-669S. Scholar google search Badaloo A., Reid M., Forrester T., Heird W.C., Jahoor F. (2002) Am. J. Clin. Nutr., 76, 646-652. Scholar google search Reid M., Badaloo A., Forerester T., Morlese J.F., Frazer M., Heird W.C., Jahoor F. (2000) Am. J. Physiol., 278, E405-E412. Scholar google search Sugherini L., Valentini M., Cambiaggi C., Tanganelli I., Gragnoli G., Borgogni P., Comporti M., Pompella A. (2000) Clin Chem. Lab. Med., 38, 983-987. CrossRef Scholar google search Cakatay U., Kayali R. (2006) Clin Biochem, 39, 907-912. CrossRef Scholar google search Blouet C., Mariotti F., Azzout-Marniche D., Mathe V., Mikogami T., Tome D., Hunneau J.F. (2007) Free Radic. Biol. Med., 42, 1089-1097. CrossRef Scholar google search