Detection of telomerase activity in gastric cancer

   
Svinareva L.V.1 , Glukhov A.I.2 , Zimnik O.V.3 , Bykov I.I.4, Khorobrykh T.V.4, Shvets V.I.5

1. Moscow Scientific Research Institute of Medical Ecology M.V. Lomonosov Moscow State Academy of Fine Chemical Technology
2. Moscow Scientific Research Institute of Medical Ecology I.M. Sechenov Moscow Medical Academy
3. Moscow Scientific Research Institute of Medical Ecology
4. I.M. Sechenov Moscow Medical Academy
5. M.V. Lomonosov Moscow State Academy of Fine Chemical Technology
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20105605602      PubMed Id: 21254631
Year: 2010  Volume: 56  Issue: 5  Pages: 602-608
Telomerase activity (TA) was examined in gastric adenocarcinomas and gastric lymphoma using a modified TRAP assay. TA was present in 16 of 18 (89%) gastric adenocarcinomas and in gastric lymphoma, whereas no TA was detected in normal tissue. Almost all samples had "high" and "very high" TA levels. Telomerase is undoubtedly associated with the process of malignant transformation and therefore can be an important marker for diagnostics of gastric cancer.
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Keywords: gastric adenocarcinoma, cancerogenesis, telomerase, telomerase activity (TA)
Citation:

Svinareva, L. V., Glukhov, A. I., Zimnik, O. V., Bykov, I. I., Khorobrykh, T. V., Shvets, V. I. (2010). Detection of telomerase activity in gastric cancer. Biomeditsinskaya khimiya, 56(5), 602-608.
This paper is also available as the English translation: 10.1134/S1990750811020168
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