Proteins-markers of placental insufficiency

   
Pogorelova T.N.1 , Gunko V.O.1 , Drukker N.A.1 , Linde V.A.1

1. Federal State Institution "Rostov Scientific Research Institute of Obstetrics and Pediatrics of Rusmedtechnologies"
Section: Short Communication
DOI: 10.18097/pbmc20105605616      UDK: 618.346: 577.11+618.3-06      PubMed Id: 21254633
Year: 2010  Volume: 56  Issue: 5  Pages: 616-620
The proteomic analysis of the amniotic fluids of women with physiological pregnancy and pregnancy, complicated with placental insufficiency has been carried out on the II and III trimesters. The following difference in protein patterns have been recognized: i) appearance of several proteins lacking in physiological pregnancy; ii) absence of several proteins detectable during physiological pregnancy - hippocalcin-like protein 1, CDC37-like protein, NKG2D ligand 2 (II trimester), CDC37-like protein, NKG2D ligand 2 (III trimester). The established differences in the amniotic fluid spectrum, obviously, have the pathogenetic meaning in the placental insufficiency development. The revealed proteins of distinction may serve as markers of this obstetrical pathology.
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Pogorelova T.N., Gunko V.O., Drukker N.A., Linde V.A. (2010) Biomeditsinskaya khimiya, 56(5), 616-620.
This paper is also available as the English translation:10.1134/S1990750811020132
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