Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)

   
Gorodetskii V.K.1, Tochilkin A.I.1, Belayeva N.F.1 , Kovelman I.R.1, Korovkin B.F.1

1. Institute of Biomedical Chemistry
Section: Short Communication
DOI: 10.18097/pbmc20115701133      UDK: 616.379-003      PubMed Id: 21516785
Year: 2011  Volume: 57  Issue: 1  Pages: 133-137
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.
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Gorodetskii V.K., Tochilkin A.I., Belayeva N.F., Kovelman I.R., Korovkin B.F. (2011) Biomeditsinskaya khimiya, 57(1), 133-137.
This paper is also available as the English translation:10.1134/S1990750811030048
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