Molecular modeling of acetylcholinesterase interaction with irreversible and reversible organophosphorous inhibitors

   
Tikhonova O.V.1 , Skvortsov V.S.1, Raevsky O.A.2

1. Institute of Biomedical Chemistry RAMS Institute of Phisiologically Active Compounds
2. Institute of Phisiologically Active Compounds
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20115701061      PubMed Id: 21516778
Year: 2011  Volume: 57  Issue: 1  Pages: 61-76
Three-dimensional Quantitative Structure-Аctivity Relationship models were designed for irreversible and reversible acetylcholinesterase inhibitors by molecular modeling methods. In case of irreversible inhibitors CoMFA (the comparative analysis of molecular fields) or CoMSIA (the comparative analysis of indexes of molecular similarity) descriptors together with HYBOT 3D fields provide more statistically valid 3D-QSAR models. This indicates importance of donor-acceptor interactions for irreversible acetylcholinesterase inhibition. In case of reversible organophosphorous inhibitors good quality model for structure-activity relationships was developed using CoMFA fields. The obtained models have good predictive power and can be used for estimation of new organophosphorous compounds inhibitor activity that in turn correlates with toxicity of these compounds.
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Keywords: Acetylcholinesterase, molecular modeling, 3D-QSAR, HYBOT 3D, reversible and irreversible inhibitors
Citation:

Tikhonova, O. V., Skvortsov, V. S., Raevsky, O. A. (2011). Molecular modeling of acetylcholinesterase interaction with irreversible and reversible organophosphorous inhibitors. Biomeditsinskaya khimiya, 57(1), 61-76.
This paper is also available as the English translation: 10.1134/S1990750810040049
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