Effects of organic selenium substance, selenomethionine,in acute alcohol intoxication

   
Petushok N.E.1 , Tarasov Yu.A.2, Pekhovskaya T.A.2, Evkovich I.N.2, Shevalye A.A.2, Chumachenko S.S.2

1. State Medical University
2. Institute of Pharmacology and Biochemistry, National Academy of Sciences of Belarus
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20115702180      PubMed Id: 21870603
Year: 2011  Volume: 57  Issue: 2  Pages: 180-186
The effect of the preliminary saturation of rats with selenomethionine (50 g/kg, intragastrically, daily, 10 days) prior to acute alcohol intoxication (5 g/kg, 20% ethanol solution, intragastrically, singly on the 11th day with the exposure for 2 hours) was investigated. The activities of glutathione peroxidases (gastrointestinal mucosa, blood plasma, erythrocytes, liver), the levels of oxidized and reduced glutathione, LPO intensity and blood corticosterone level were studied.
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Keywords: selenomethionine, ethanol, glutathione peroxidases, glutathione, gastrointestinal tract, corticosterone
Citation:

Petushok, N. E., Tarasov, Yu. A., Pekhovskaya, T. A., Evkovich, I. N., Shevalye, A. A., Chumachenko, S. S. (2011). Effects of organic selenium substance, selenomethionine,in acute alcohol intoxication. Biomeditsinskaya Khimiya, 57(2), 180-186.
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