Influence of α-lipoic acid on liver glutathione system of healthy and ehrlich ascites carcinoma transplanted mice

   
Kolesnichenko L.S.1, Laletin V.S.1 , Kulinsky V.I.1

1. Irkutsk state medical university
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20115702219      PubMed Id: 21870608
Year: 2011  Volume: 57  Issue: 2  Pages: 219-224
Influence of α-lipoic acid (LA) on liver glutathione system of Ehrlich ascites carcinoma (EAC) transplanted mice was studied. LA causes multidirectional influence on glutathione system of healthy mice. EAC transforms LA influence, strengthening prooxidative effects more expressed at introduction in early terms after inoculation of the tumor. The mechanism explaining realization of LA prooxidative effects as a result of interaction with glutathione system is suggested.
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Keywords: glutathione system, α-lipoic acid, Ehrlich ascites carcinoma, lipid peroxidation
Citation:

Kolesnichenko, L. S., Laletin, V. S., Kulinsky, V. I. (2011). Influence of α-lipoic acid on liver glutathione system of healthy and ehrlich ascites carcinoma transplanted mice. Biomeditsinskaya Khimiya, 57(2), 219-224.
This paper is also available as the English translation: 10.1134/S1990750810040086
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