Glutathione-dependent enzymes and glucose-6-phosphate dehydrogenase of blood in patients with lymphosarcoma (non-hodgkin's disease)

   
Gavriliuc L.A.1 , Corcimaru I.F.1, Robu M.V.1, Lisii L.T.1

1. State University of Medicine and Pharmacy "N.Testemitanu"
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20115702225      UDK: 612.015.11:616-006.441      PubMed Id: 21870609
Year: 2011  Volume: 57  Issue: 2  Pages: 225-231
Activities of glutathione-dependent enzymes and glucose-6-phosphate dehydrogenase (GPDH) were studied in blood of the patients with lymphosarcoma (LS). The activity of glutathione reductase (GR), glutathione dehydroascorbate reductase (GDAR), gamma-glutamyltranspeptidase (GGT) and G6PDH in plasma, leucocytes, lymphocytes and erythrocytes of peripheral blood in 30 patients (42-56 years) with LS and in 20 healthy have been determined with spectrophotometric methods (Humalyzer 2000 DE). Leucocytes and lymphocytes were separated from blood using Boyum method. Spearmen method used for correlative analysis. The levels of enzymes activity and results of correlative analysis showed an imbalance of antioxidative system defense and metabolic disturbances in patients with LS. The strong functional interrelation was estimated only between GR and G6PDH in the patients' lymphocytes (r=+0,716; p<0.0005). Interrelation was found between the levels of activity of antioxidative enzymes and activity (stage) of pathologic process, this may be used as the additional biochemical test for differential diagnostics of LS and estimation of the cells proliferative activity.
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Gavriliuc L.A., Corcimaru I.F., Robu M.V., Lisii L.T. (2011) Biomeditsinskaya khimiya, 57(2), 225-231.
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