Sustained release of the antitumor drug paclitaxel from poly(3-hydroxybutyrate)-based microspheres

   
Bonartsev A.P.1, Soboleva G.M.2, Shaytan K.V.2, Kirpichnikov M.P.2, Yakovlev S.G.3, Filatova E.V.3, Makhina T. K.3, Bonartseva G.A.3, Popov V.O.3

1. Lomonosov Moscow State University, Bakh Institute of Biochemistry RAS
2. School of Biology, M.V. Lomonosov Moscow State University
3. Bakh Institute of Biochemistry RAS, Moscow, Russia
Section: Short Communication
DOI: 10.18097/PBMC20115702232      PubMed Id: 21870610
Year: 2011  Volume: 57  Issue: 2  Pages: 232-240
Development of systems of medicines with sustained action on the basis of biodegradable polymers is a promising trend in modern pharmacology. Polyhydroxyalkanoates (POA) attract increasing attention due to their biodegradability and high biocompatibility, which make them suitable for development of novel drug dosage forms. We obtained microspheres on the basis of poly(3-hydroxybutyrate) (PHB) loaded with the antitumor drug paclitaxel. Morphology, drug release kinetics and effect on tumor cells in vitro of microspheres were studied. The data on the kinetics of drug release, biocompatibility and biological activity of the biopolymer microspheres in vitro showed that the studied system of prolonged drug release had lower toxicity and higher efficiency compared to the traditional dosage forms of paclitaxel.
Download PDF:  
Keywords: poly(3-hydroxybutyrate), paclitaxel, microspheres, sustained release, anticancer
Citation:

Bonartsev, A. P., Soboleva, G. M., Shaytan, K. V., Kirpichnikov, M. P., Yakovlev, S. G., Filatova, E. V., Makhina, T. , K., Bonartseva, G. A., Popov, V. O. (2011). Sustained release of the antitumor drug paclitaxel from poly(3-hydroxybutyrate)-based microspheres. Biomeditsinskaya Khimiya, 57(2), 232-240.
This paper is also available as the English translation: 10.1134/S1990750812010027
References  
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)