1. A.N. Bach Institute of Biochemistry, Russian Academy of Medical Sciences 2. Russian Medical Academy of Postgraduate Education 3. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Two isoforms of Dj-1 protein were identified using a proteomic study in tissue specimens from two groups of patients with confirmed benign prostate hyperplasia (BPH) and prostate cancer (PCa). Dj-1 was also found in the cell lines РС-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. Immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant distinctions between two groups of patients (р=0,004, Mann-Whitney test) only for Dj-1. Taken together, these data suggest that Dj-1 protein is a perspective biomarker candidate for PCa.
Lisitskaya K.V., Eremina L.S., Ivanov A.V., Kovalyova M.A., Okhrits V.E., Toropygin I.Y., Kovalyov L.I., Shishkin S.S. (2011) Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients. Biomeditsinskaya Khimiya, 57(4), 392-401.
Lisitskaya K.V. et al. Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients // Biomeditsinskaya Khimiya. - 2011. - V. 57. -N 4. - P. 392-401.
Lisitskaya K.V. et al., "Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients." Biomeditsinskaya Khimiya 57.4 (2011): 392-401.
Lisitskaya, K. V., Eremina, L. S., Ivanov, A. V., Kovalyova, M. A., Okhrits, V. E., Toropygin, I. Y., Kovalyov, L. I., Shishkin, S. S. (2011). Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients. Biomeditsinskaya Khimiya, 57(4), 392-401.
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