Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

Lisitskaya K.V.1, Eremina L.S.1, Ivanov A.V.1, Kovalyova M.A.1, Okhrits V.E.2, Toropygin I.Y.3, Kovalyov L.I.1, Shishkin S.S.1

1. A.N. Bach Institute of Biochemistry, Russian Academy of Medical Sciences
2. Russian Medical Academy of Postgraduate Education
3. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20115704392      PubMed Id: 22066264
Year: 2011  Volume: 57  Issue: 4  Pages: 392-401
Two isoforms of Dj-1 protein were identified using a proteomic study in tissue specimens from two groups of patients with confirmed benign prostate hyperplasia (BPH) and prostate cancer (PCa). Dj-1 was also found in the cell lines РС-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. Immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant distinctions between two groups of patients (р=0,004, Mann-Whitney test) only for Dj-1. Taken together, these data suggest that Dj-1 protein is a perspective biomarker candidate for PCa.
Download PDF:  
Keywords: Dj-1, prostate cancer, two-dimensional electrophoresis, ELISA

Lisitskaya, K. V., Eremina, L. S., Ivanov, A. V., Kovalyova, M. A., Okhrits, V. E., Toropygin, I. Y., Kovalyov, L. I., Shishkin, S. S. (2011). Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients. Biomeditsinskaya Khimiya, 57(4), 392-401.
This paper is also available as the English translation: 10.1134/S1990750811010070
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)