1. Sechenov First Moscow State Medical University
Scientific Center for Expertise of Medical Products 2. Scientific Center for Expertise of Medical Products 3. Sechenov First Moscow State Medical University
The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined. In addition, the dissolution characteristics of APIs from different BCS classes in biorelevant media are described. Possible applications of biorelevant media in regulatory practice and science are also shown.
Ramenskaya G.V. et al. The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo // Biomeditsinskaya khimiya. - 2011. - V. 57. -N 5. - P. 482-489.
Ramenskaya G.V. et al., "The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo." Biomeditsinskaya khimiya 57.5 (2011): 482-489.
Ramenskaya, G. V., Shohin, I. E., Savchenko, A. Y., Volkova, E. A. (2011). The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo. Biomeditsinskaya khimiya, 57(5), 482-489.
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