Antioxidant system state in patients with multiple sclerosis current in therapy

Smirnova L.P.1 , Krotenko N.V.2, Grishko E.V.1, Krotenko N.M.2, Alifirova V.M.2, Ivanova S.A.1

1. Institution of Russian Academy of Medical Sciences, Mental Health Research Institute
2. Siberian State Medical University of Federal Agency on Healthcare and Social Development
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20115706661      PubMed Id: 22359923
Year: 2011  Volume: 57  Issue: 6  Pages: 661-670
Activity of erytrocyte glutationperoxidase (GP), glutationreductase (GR), glutationtransferase (GT), glucose-6-phosphatdehydrogenase (G6PDH), catalase and superoxiddysmutase (SOD), and also, the level of malonic dialdehyde (MDA) and total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis. Investigation of peripherical blood was carried out on first day of treatment and after standard therapy of copaxone. All MS patients had high level of MDA and activity of GP in erythrocytes in comparison with a control group. Other antioxidant enzymes of erythrocytes and total antioxidant activity of blood serum exhibited weak positive dynamics in patients with a relapsing remittance of multiple sclerosis (RRMS). Decrease of activity of antioxidant system in patients with secondary progression multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with the more severe clinical course of thise disease.
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Keywords: oxidative stress, antioxidant enzymes, multiple sclerosis

Smirnova, L. P., Krotenko, N. V., Grishko, E. V., Krotenko, N. M., Alifirova, V. M., Ivanova, S. A. (2011). Antioxidant system state in patients with multiple sclerosis current in therapy. Biomeditsinskaya Khimiya, 57(6), 661-670.
This paper is also available as the English translation: 10.1134/S1990750811010136
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