The increase of bioavailability and antiinflammatory effect of indomethacin included into phospholipid nanoparticles

   
Shironin A.V.1, Ipatova O.M.1, Medvedeva N.V.1, Prozorovskiy V.N.1, Tikhonova E.G.1, Zakharova T.S.1, Sanzhakov M.A.1, Torkhovskaya T.I.1

1. Institute of Biomedical Chemistry, Russian Academy of Sciences
Section: Short Communication
DOI: 10.18097/pbmc20115706671      PubMed Id: 22359924
Year: 2011  Volume: 57  Issue: 6  Pages: 671-676
The ultrafine formulation on the base of plant phosphatidylcholine and antiinflammatory remedy indomethacin with nanoparticles less than 50 nm was obtained. Drug bioavailability after its peroral administration to rats was more than 2 fold higher as compared with free indomethacin. Increased antiinflammatory activity of indomethacin in phospholipids nanoparticles as compared with its free form was shown in two models of inflammation - adjuvant arthritis in rats and conconavalin A induced edema in mice. The increased bioavailability of indomethacin after administration of its phospholipid formulation allows to decrease a dose for achievement of therapeutic effect, that reduces risks of occurrence of collateral displays.
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Keywords: indomethacin, phospholipids nanoparticles, absorption, conconavalin A, antiinflammatory action
Citation:

Shironin, A. V., Ipatova, O. M., Medvedeva, N. V., Prozorovskiy, V. N., Tikhonova, E. G., Zakharova, T. S., Sanzhakov, M. A., Torkhovskaya, T. I. (2011). The increase of bioavailability and antiinflammatory effect of indomethacin included into phospholipid nanoparticles. Biomeditsinskaya khimiya, 57(6), 671-676.
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