Peculiar properties of glutathione system and nadph-generated enzymes functioning in blood of patients with drug-induced hepatitis under combined treatment with epifamin

   
Popov S.S.1 , Shulgin K.K.2, Pashkov A.N.1, Zoloyedov V.I.1, Shvedov G.I.1, Rakhmanova T.I.2

1. Burdenko Voronezh State Medical Academy
2. Voronezh State University
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125801104      PubMed Id: 22642157
Year: 2012  Volume: 58  Issue: 1  Pages: 104-111
Activity of the glutathione antioxidant system has been studied in patients with drug-induced hepatitis treated with standart base therapy and combined with epifamin therapy. In blood serum of patients beforе treatment the decrease of reduced glutathione (GSH) level and the increase of glutathione peroxidase (GP) and glutathione reductase (GR) activities versus control were observed. Combined treatment with epifamin changed GSH level to the normal values. Treatment with epifamin was accompanied by pronounced increase in GP and GR activities compared with standard therapy. Activities of the NADPH-generated enzymes, glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase, which decreased at this pathology, also demonstrated a more significant increase than standart treatment.
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Keywords: drug-induced hepatitis, glutathione antioxidant system, hepatoprotectors, epifamin
Citation:

Popov, S. S., Shulgin, K. K., Pashkov, A. N., Zoloyedov, V. I., Shvedov, G. I., Rakhmanova, T. I. (2012). Peculiar properties of glutathione system and nadph-generated enzymes functioning in blood of patients with drug-induced hepatitis under combined treatment with epifamin. Biomeditsinskaya khimiya, 58(1), 104-111.
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