This review is devoted to antimicrobial peptides (AMP's) that demonstrate activity against bacteria, viruses and fungi. It considers structure and mechanism of AMP interaction with lipid membrane and intracellular targets of pathogens. Special attention is paid to modern state and perspectives of AMP practical application and also to approaches that increase efficacy and reduce toxicity of AMP by chemical modification of their structure.
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Keywords: antimicrobial peptides, mode of action, practical application
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Okorochenkov S.A., Zheltukhina G.A., Nebol"sin V.E. (2012) Antimicrobial peptides: mode of action and perspectives of practical application. Biomeditsinskaya Khimiya, 58(2), 131-143.
Okorochenkov S.A. et al. Antimicrobial peptides: mode of action and perspectives of practical application // Biomeditsinskaya Khimiya. - 2012. - V. 58. -N 2. - P. 131-143.
Okorochenkov S.A. et al., "Antimicrobial peptides: mode of action and perspectives of practical application." Biomeditsinskaya Khimiya 58.2 (2012): 131-143.
Okorochenkov, S. A., Zheltukhina, G. A., Nebol"sin, V. E. (2012). Antimicrobial peptides: mode of action and perspectives of practical application. Biomeditsinskaya Khimiya, 58(2), 131-143.
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