Antimicrobial peptides: mode of action and perspectives of practical application

   
Okorochenkov S.A.1, Zheltukhina G.A.1 , Nebol"sin V.E.2

1. M.V. Lomonosov Moscow State Academy of Fine Chemical Technology
2. LTD "Pharmenterprises"
Section: Review
DOI: 10.18097/pbmc20125802131      UDK: 577.112.6: 577.18.02      PubMed Id: 22724354
Year: 2012  Volume: 58  Issue: 2  Pages: 131-143
This review is devoted to antimicrobial peptides (AMP's) that demonstrate activity against bacteria, viruses and fungi. It considers structure and mechanism of AMP interaction with lipid membrane and intracellular targets of pathogens. Special attention is paid to modern state and perspectives of AMP practical application and also to approaches that increase efficacy and reduce toxicity of AMP by chemical modification of their structure.
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Okorochenkov S.A., Zheltukhina G.A., Nebol"sin V.E. (2012) Biomeditsinskaya khimiya, 58(2), 131-143.
This paper is also available as the English translation:10.1134/S1990750811020120
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