Mechanisms of anti-cancer effects of polyphenols, found in fruits, vegetables, spices and representing parts of daily nutrition, have been considered. These compounds may be the basis for development of cancer preventive preparations. They can block carcinogenesis initiation by inactivation of exogenous or endogenous genotoxic molecules including reactive oxygen species. Another mechanism consists in inhibition of activity and synthesis of carcinogen-metabolizing enzymes. Plant polyphenols also induce expression of antioxidant and detoxification enzymes genes.
Download PDF:
Keywords: plant polyphenols, carcinogenesis initiation, inactivation of genotoxic molecules, inhibition of metabolic activation of carcinogens, induction of antioxidant and detoxification enzymes
Citation:
Zinov"eva V.N., Spasov A.A. (2012) Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation. Biomeditsinskaya Khimiya, 58(2), 160-175.
Zinov"eva V.N. et al. Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation // Biomeditsinskaya Khimiya. - 2012. - V. 58. -N 2. - P. 160-175.
Zinov"eva V.N. et al., "Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation." Biomeditsinskaya Khimiya 58.2 (2012): 160-175.
Zinov"eva, V. N., Spasov, A. A. (2012). Mechanisms of plant polyphenols anti-cancer effects I. Blockade of carcinogenesis initiation. Biomeditsinskaya Khimiya, 58(2), 160-175.
Chang T.K., Chen J., Lee W.B. (2001) J. Pharmacol. Exp. Ther., 299, 874-882. Scholar google search
Chen Z.H., Hurh Y.J., Na H.K., Kim J.H., Chun Y.J., Kim D.H., Kang K.S., Cho M.H., Surh Y.J. (2004) Carcinogenesis, 25, 2005-2013. Scholar google search
Chun Y.J., Ryu S.Y., Jeong T.C., Kim M.Y. (2001) Drug Metab. Dispos., 29, 389-393. Scholar google search
Zahid M., Gaikwad N.W., Ali M.F., Lu F., Saeed M., Yang L., Rogan E.G., Cavalier E.L. (2008) Free Radic. Biol. Med., 45, 136-145. CrossRef Scholar google search
Shen G., Xu C., Hu R., Jain M.R., Nair S., Lin W., Yang C.S., Chan J.Y., Kong A.N. (2005) Pharm. Res., 22, 1805-1820. CrossRef Scholar google search
Balogun E., Hoque M., Gong P., Killeen E., Green C.J., Foresti R., Alam J., Motterlini R. (2003) Biochem. J., 371, 887-895. CrossRef Scholar google search
Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D., Kang M.-I., Kobayashi A., Yamamoto M., Kensler T.W., Talalay P. (2004) Proc. Natl. Acad. Sci., 101, 2040-2045. CrossRef Scholar google search
Rushworth S.A., Ogborne R.M., Charalambos C.A., O`Connell M.A. (2006) Biochem. Biophys. Res. Commun., 341, 1007-1016. CrossRef Scholar google search
Athar M., Back J.H., Tang X., Kim K.H., Kopelovich L., Bickers D.R., Kim A.L. (2007) Toxicol. Appl. Pharmacol., 224, 274-283. CrossRef Scholar google search
Farombi E.O., Shrotriya S., Na H.K., Kim S.H., Surh Y.J. (2008) Food Chem. Toxicol., 46, 1279-1287. CrossRef Scholar google search
Shen G., Xu C., Hu R., Jain M.R., Gopalkrishnan A., Nair S., Huang M.-T., Chan J.Y., Kong A.-N.T. (2006) Mol. Cancer Ther., 1, 39-51. CrossRef Scholar google search
Harris G.K., Gupta A., Nines R.G., Kresty L.A., Habib S.G., Frankel W.L., LaPerle K., Gallaher D.D., Schwartz S.J., Stoner G.D. (2001) Nutr. Cancer, 40, 125-133. CrossRef Scholar google search
Revel A., Raanani H., Younglai E., Xu J., Rogers I., Han R., Savouret J.F., Casper R.F. (2003) J. Appl. Toxicol., 23, 255-261. CrossRef Scholar google search
Berge G., Ovrebo S., Eilertsen E., Haugen A., Mollerup S. (2004) Br. J. Cancer, 91, 1380-1383. CrossRef Scholar google search
