Particularities of corrective action of polar lipids and bioantioxidants from sea hydrobionts at imbalances of lipid and carbohydrate metabolism

   
Krivoshapko O.N.1, Popov A.M.1 , Artyukov A.A.1, Kostetsky E.Y.2

1. Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science
2. Far East State University
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125802189      PubMed Id: 22724358
Year: 2012  Volume: 58  Issue: 2  Pages: 189-198
A total mixture of phospho- and glycolipids from sea macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. Biological activity of the mixtures of polar lipids and natural antioxidants echinochrome A from flat sea urchin Scaphechinus mirabilis and polyphenolic complex from sea grass Zostera marina was studied in rats with experimental model of atherosclerosis and diabetes. These experiments revealed optimal compositions for mixtures of polar lipids and antioxidants, which possess high medical-corrective activity. Proposed mechanisms of action of the polar lipids (containing different polyunsaturated fatty acids) and antioxidants studied are presented. These compositions may be used for creation of new biologically-active additives and drugs.
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Keywords: polar lipids, luteolin, rosmarinic acid, diabetes, hyperlipidemia, 1,4-naphtoquinones
Citation:

Krivoshapko, O. N., Popov, A. M., Artyukov, A. A., Kostetsky, E. Y. (2012). Particularities of corrective action of polar lipids and bioantioxidants from sea hydrobionts at imbalances of lipid and carbohydrate metabolism. Biomeditsinskaya khimiya, 58(2), 189-198.
This paper is also available as the English translation: 10.1134/S1990750811020053
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