New bioaffine sorbents for selective elimination of autoantibodies against human thyroperoxidase in autoimmune thyroid diseases

   
Gribovskaya O.V.1 , Shutova I.V.1, Tsyganova O.V.1, Martinovich V.P.1, Golubovich V.P.1

1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125802211      PubMed Id: 22724360
Year: 2012  Volume: 58  Issue: 2  Pages: 211-219
New bioaffine sorbents containing bioselective ligand, synthetic analog of the human thyroperoxidase antigenic determinant - tetrapeptide H-Glu-Gln-βAla-Lys-OMe, immobilized on two polymeric matrixes - a polyacrylamide gel and CNBr-activated sepharose 4B were synthesized. The offered immunosorbents were shown have high selectivity in relation to autoantibodies against thyroperoxidase and can find an application for medicine and experimental biochemistry for selective elimination of autoantibodies from serum or plasma of the patients suffering from autoimmune thyroid diseases.
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Keywords: peptide synthesis, bioaffine sorbents, in silico design, autoantibodies against thyroperoxidase, autoimmune thyroid diseases
Citation:

Gribovskaya, O. V., Shutova, I. V., Tsyganova, O. V., Martinovich, V. P., Golubovich, V. P. (2012). New bioaffine sorbents for selective elimination of autoantibodies against human thyroperoxidase in autoimmune thyroid diseases. Biomeditsinskaya khimiya, 58(2), 211-219.
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