Mechanisms of suppression of carcinogenesis promotion/progression by plant polyphenols have been considered. They can decrease cyclins and cycline dependent kinases and activate inhibitor proteins in tumor cells that results in cell cycle arrest. Plant polyphenols can induce apoptosis by modulating anti/proapoptotic proteins and also can inhibit tumor metastasis and angiogenesis. Polyphenols act through the regulation of cell signal transduction and gene expression.
Download PDF:
Keywords: plant polyphenols, carcinogenesis promotion/progression, cell cycle arrest, apoptosis induction, inhibition of tumor metastasis and angiogenesis, modulation of cell signal transduction
Citation:
Zinov'eva V.N., Spasov A.A. (2012) Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth. Biomeditsinskaya Khimiya, 58(3), 257-271.
Zinov'eva V.N. et al. Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth // Biomeditsinskaya Khimiya. - 2012. - V. 58. -N 3. - P. 257-271.
Zinov'eva V.N. et al., "Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth." Biomeditsinskaya Khimiya 58.3 (2012): 257-271.
Zinov'eva, V. N., Spasov, A. A. (2012). Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth. Biomeditsinskaya Khimiya, 58(3), 257-271.
Dhillon N., Wolff R.A., Abbruzzese J.L., Hong D.S., Camacho L.H., Li L., Braiteh F.S., Kurzrock R. (2006) J. Clin. Oncol., 24, 14151. Scholar google search
Jatoi A., Ellison N., Burch P., Sloan J., Dakhil S., Novotny P., Tan W., Fitch T., Rowland K., Young C., Flynn P. (2003) Cancer, 97,1442-1446. CrossRef Scholar google search
Ragione F.D., Cucciolla V., Borriello A., Pietra V.D., Racioppi L., Soldati G., Manna C., Galletti P., Zappia V. (1998) Biochem. Biophys. Res. Commun., 250, 53-58. CrossRef Scholar google search
Park J.W., Choi Y.J., Jang M.A., Lee Y.S., Jun D.Y., Suh S.I., Baek W.K., Suh M.H., Jin I.N., Kwon T.K. (2001) Cancer Lett., 163, 43-49. CrossRef Scholar google search
Schneider Y., Vincent F., Duranton B., Badolo L., Gosse F., Bergmann C., Seiler N., Raul F. (2000) Cancer Lett., 158, 85-91. CrossRef Scholar google search
Sgambato A., Ardito R., Faraglia B., Boninsegna A., Wolf F.I., Cittadini A. (2001) Mutat. Res., 496, 171-180. CrossRef Scholar google search
Ahmad N., Adhami V.M., Afaq F., Feyes D.K., Mukhtar H. (2001) Clin. Cancer Res., 7, 1466-1473. Scholar google search
Joe A.K., Liu H., Suzui M., Vural M.E., Xiao D., Weinstein I.B. (2002) Clin. Cancer Res., 8, 893-903. Scholar google search
Constantinou A.I., Krygier A.E., Mehta R.R. (1998) Am. J. Clin. Nutr., 68, 1426S-1430S. Scholar google search
LoTempio M., Veena M., Steele H., Ramamurthy B., Ramalingam T., Cohen A., Chakrabarti R., Srivatsan E., Wang M. (2005) Clin. Cancer Res., 11, 6994-7002. CrossRef Scholar google search
Nishikawa T., Nakajima T., Moriguchi M., Jo M., Sekoguchi S., Ishii M., Takashima H., Katagishi T., Kimura H., Minami M., Itoh Y., Kagawa K., Okanoue T. (2006) J. Hepatol., 44, 1074-1082. CrossRef Scholar google search
Shankar S., Srivastava R.K. (2007) Int. J. Oncol., 30(4), 905-918. Scholar google search
D`Archivio M., Santangelo C., Scazzocchio B., Vari R., Filesi C., Masella R., Giovannini C. (2008) Int. J. Mol. Sci., 9, 213-228. CrossRef Scholar google search
Rowe D.L., Ozbay T., O`Regan R.M., Nahta R. (2009) Breast Cancer, 3, 61-75. Scholar google search
Shao Z.M., Shen Z.Z., Liu C.H., Sartippour M.R., Go V.L., Heber D., Nguyen M. (2002) Int. J. Cancer, 98, 234-240. CrossRef Scholar google search
Coates E.M., Popa G., Gill C.I., McCann M.J., McDougall G.J., Stewart D., Rowland I. (2007) J. Carcinog., 6, 4. CrossRef Scholar google search
Kato K., Long N.K., Makita H., Toida M., Yamashita T., Hatakeyama D., Hara A., Mori H., Shibata T. (2008) Br. J. Cancer, 99, 647-654. CrossRef Scholar google search
Azios N.G., Krishnamoorthy L., Harris M., Cubano L.A., Cammer M., Dharmawardhane S.F. (2007) Neoplasia, 9, 147-158. CrossRef Scholar google search
Sagar S.M., Yance D., Wong R.K. (2006) Curr. Oncol., 13(1), 14-26. Scholar google search
Huang C., Li J., Song L., Zhang D., Tong Q., Ding M., Bowman L., Aziz R., Stoner G.D. (2006) Cancer Res., 66, 581-587. CrossRef Scholar google search
Woo J.H., Lim J.H., Kim Y.H., Suh S.I., Min D.S., Chang J.S., Lee Y.H., Park J.W., Kwon T.K. (2004) Oncogene, 23, 1845-1853. CrossRef Scholar google search
Kotha A., Sekharam M., Cilenti L., Siddiquee K., Khaled A., Zervos A.S., Carter B., Turkson J., Jove R. (2006). Mol. Cancer Ther., 5, 621-629. CrossRef Scholar google search
