Manganese in atherogenesis: detection, origin, and role

Lozhkin A.P.1 , Biktagirov T.B.1, Gorshkiv O.V.2, Timonina E.V.1, Mamin G.V.1, Orlinskii S.B.1, Silkin N.I.1, Chernov V.M.2, Khairullin R.N.3, Salakhov M.Kh.1, Ilinskaya O.N.1, Abdul'yanov V.A.3

1. Kazan State University
2. Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center of RAS
3. Interregional Clinical Diagnostic Center
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20125803291      PubMed Id: 22856134
Year: 2012  Volume: 58  Issue: 3  Pages: 291-299
The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis.
Download PDF:  
Keywords: atherosclerosis, superoxide dismutase, manganese, sodA gene

Lozhkin, A. P., Biktagirov, T. B., Gorshkiv, O. V., Timonina, E. V., Mamin, G. V., Orlinskii, S. B., Silkin, N. I., Chernov, V. M., Khairullin, R. N., Salakhov, M. Kh., Ilinskaya, O. N., Abdul'yanov, V. A. (2012). Manganese in atherogenesis: detection, origin, and role. Biomeditsinskaya Khimiya, 58(3), 291-299.
This paper is also available as the English translation: 10.1134/S1990750811020090
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)