A covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate (SOD-CHS-CAT) demonstrated the dose-dependent inhibitory action on induced aggregation of platelets in the presence of hydrogen peroxide. Antioxidant activity of SOD-CHS-CAT appeared at much lower doses than for other CAT derivatives. We detected the antiaggregation effect of SOD-CHS-CAT for platelet aggregation induced by ADP, serotonin, TRAP (with their different mechanism of action). Novel properties of SOD-CHS-CAT confirmed with its action agains spread-eagle platelets on glass surface. The new characteristics of SOD-CHS-CAT conjugate underline the prospects of its biopharmaceutical development for antioxidant therapy.
Vavaev A.V. et al. Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase - chondroitin sulfate - catalase conjugate in platelet interactions // Biomeditsinskaya Khimiya. - 2012. - V. 58. -N 3. - P. 300-309.
Vavaev A.V. et al., "Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase - chondroitin sulfate - catalase conjugate in platelet interactions." Biomeditsinskaya Khimiya 58.3 (2012): 300-309.
Vavaev, A. V., Buryachkovskaya, L. I., Tischenko, E. G., Uchitel, I. A., Maksimenko, A. V. (2012). Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase - chondroitin sulfate - catalase conjugate in platelet interactions. Biomeditsinskaya Khimiya, 58(3), 300-309.
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