Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase - chondroitin sulfate - catalase conjugate in platelet interactions

   
Vavaev A.V.1, Buryachkovskaya L.I.1, Tischenko E.G.1, Uchitel I.A.1, Maksimenko A.V.1

1. Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125803300      UDK: 577.152.3      PubMed Id: 22856135
Year: 2012  Volume: 58  Issue: 3  Pages: 300-309
A covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate (SOD-CHS-CAT) demonstrated the dose-dependent inhibitory action on induced aggregation of platelets in the presence of hydrogen peroxide. Antioxidant activity of SOD-CHS-CAT appeared at much lower doses than for other CAT derivatives. We detected the antiaggregation effect of SOD-CHS-CAT for platelet aggregation induced by ADP, serotonin, TRAP (with their different mechanism of action). Novel properties of SOD-CHS-CAT confirmed with its action agains spread-eagle platelets on glass surface. The new characteristics of SOD-CHS-CAT conjugate underline the prospects of its biopharmaceutical development for antioxidant therapy.
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Vavaev A.V., Buryachkovskaya L.I., Tischenko E.G., Uchitel I.A., Maksimenko A.V. (2012) Biomeditsinskaya khimiya, 58(3), 300-309.
This paper is also available as the English translation:10.1134/S199075081102017X
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