It was shown that glucose in concentration 12.5-100 mM stimulated of Cu2+-mediated free radical peroxidation of low density lipoproteins (LDL) from human blood plasma. On the base investigation of kinetic parameters of LDL peroxidation it was stated that intensification of this process in the conditions of our experiments is caused by formation of free radical intermediates of glucose autoxidation during active oxygen species generation in the presence of metal ions with variable valence. It was found that glucose level normalization in the blood of patients with type 2 diabetes during therapy accompanied by significant decreasing of LDL oxidizing. During therapy with sugar-lowering drug metformin which utilizate methylglyoxal the LDL peroxidation from blood diabetes mellitus in vivo inhibited in more higher degree probably in consequence of decreasing of methylglyoxal-dependent generation of superoxide anion radicals as was shown by us early [Biochemistry (Moscow), 2007, 72: 1081-1090; Biochemistry (Moscow), 2009, 74: 461-466].
Lankin V.Z., Konovalova G.G., Tikhaze A.K., Nedosugova L.V. (2012) The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo. Biomeditsinskaya Khimiya, 58(3), 339-352.
Lankin V.Z. et al. The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo // Biomeditsinskaya Khimiya. - 2012. - V. 58. -N 3. - P. 339-352.
Lankin V.Z. et al., "The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo." Biomeditsinskaya Khimiya 58.3 (2012): 339-352.
Lankin, V. Z., Konovalova, G. G., Tikhaze, A. K., Nedosugova, L. V. (2012). The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo. Biomeditsinskaya Khimiya, 58(3), 339-352.
Lankin V.Z., Tikhaze A.K. (2003) in: Free Radicals, Nitric Oxide, and Inflammation: Molecular, Biochemical, and Clinical Aspects, NATO Science Series vol. 344 (Tomasi A. et al., eds.) IOS Press, Amsterdam etc., pp. 218-231. Scholar google search
Kawamura M., Heinecke J.W., Chait A. (1994) J.Clin.Invest., 94, 771-778. Scholar google search
Kuzuya M., Yamada K., Hayashi T., Funaki C., Naito M., Asai K., Kuzuya F. (1992) Biochim. Biophys. Acta, 1123, 334-341. Scholar google search
Lankin V.Z. (2003) in: Free Radicals, Nitric Oxide, and Inflammation: Molecular, Biochemical, and Clinical Aspects, NATO Science Series vol. 344 (Tomasi A. et al., eds.) IOS Press, Amsterdam etc., pp. 8-23. Scholar google search
Lankin V.Z., Antonovsky V.L., Tikhaze A.K. (2004) in: Peroxides at the Beginning of the Third Millennium (Antonovsky V.L. et al., eds.) Nova Science Publishers Inc., New York, pp. 85-111. Scholar google search
Emmanuel N.M., Lyaskovskaja Ju.N. (1961) Tormozhenie processov okislenija zhirov, Pishhepromizdat, M., str.10-19 Scholar google search
Lankin V.Z., Konovalova G.G., Tihaze A.K., Nezhdanova I.B., Olferev A.N., Kuharchuk V.V. (2003) Bulletin of experimental biology and medicine, 136, 49-52. Scholar google search
Beisswenger P., Howell S., Touchette A., Lai S., Szwergold B. (1999) Diabetes, 48, 198-202. Scholar google search
Ruggiero-Lopez D., Lecomte M., Moinet G., Patereau G., Lagarde M., Wiernsperger N. (1999) Biochem. Pharmacol., 58, 1765-1773. Scholar google search
Beisswenger P., Ruggiero-Lopez D (2003) Diabetes Metab., 29, 6S95-6S103. Scholar google search
Jain S.K., McVie R., Jackson R., Levine S.N., Lim G. (1999) Diabetes Care, 22, 1171-1175. Scholar google search
Galvani S., Coatrieux C., Elbaz M., Grazide M.H., Thiers J.C., Parini A., Uchida K., Kamar N., Rostaing L., Baltas M., Salvayre R., Negre-Salvayre A. (2008) Free Radic. Biol. Med., 45, 1457-1467. Scholar google search
Belkheiri N., Bouguerne B., Bedos-Belval F., Duran N., Bernis C., Salvayre R., Negre-Salvayre A., Baltas M. (2010) Eur. J. Med. Chem., in press. Scholar google search
