The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo

   
Lankin V.Z.1 , Konovalova G.G.1, Tikhaze A.K.1, Nedosugova L.V.1

1. Russian Cardiology Research Complex
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125803339      PubMed Id: 22856139
Year: 2012  Volume: 58  Issue: 3  Pages: 339-352
It was shown that glucose in concentration 12.5-100 mM stimulated of Cu2+-mediated free radical peroxidation of low density lipoproteins (LDL) from human blood plasma. On the base investigation of kinetic parameters of LDL peroxidation it was stated that intensification of this process in the conditions of our experiments is caused by formation of free radical intermediates of glucose autoxidation during active oxygen species generation in the presence of metal ions with variable valence. It was found that glucose level normalization in the blood of patients with type 2 diabetes during therapy accompanied by significant decreasing of LDL oxidizing. During therapy with sugar-lowering drug metformin which utilizate methylglyoxal the LDL peroxidation from blood diabetes mellitus in vivo inhibited in more higher degree probably in consequence of decreasing of methylglyoxal-dependent generation of superoxide anion radicals as was shown by us early [Biochemistry (Moscow), 2007, 72: 1081-1090; Biochemistry (Moscow), 2009, 74: 461-466].
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Keywords: oxidative stress, carbonyl stress, modified low density lipoproteins, glucose, lipohydroperoxides, malondialdehyde, methylglyoxal, metformin
Citation:

Lankin, V. Z., Konovalova, G. G., Tikhaze, A. K., Nedosugova, L. V. (2012). The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo. Biomeditsinskaya khimiya, 58(3), 339-352.
This paper is also available as the English translation: 10.1134/S1990750811030061
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