The influence of afobazole on biochemical and histo-patho-morphological parameters of endothelial function at experimental diabetes mellitis in rats

Dzugkoev S.G.1, Kozyrev K.M.2, Gumanova N.G.3, Dzugkoeva F.S.1

1. ERAS institute of biomedical researches of Vladikavkaz centre of science of the Russian Academy of Science and Government RNO-Alania
2. SEE HPE North-Ossetian State medical academy of Roszdrav
3. National research center for preventive medicine of the Ministry of Health of the Russian Federation
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125804438      UDK: 577.352.3      PubMed Id: 23413688
Year: 2012  Volume: 58  Issue: 4  Pages: 438-445
Oxidizing stress in rats with experimental diabetes mellitis is accompanied by endothelial dysfunction develops. Its biochemical markers are the increase of concentration of blood MDA, the impairments of cell antioxidant depence and a decrease in concentration of total metabolites of NO and expression of endothelial NO-synthetase (e-NOS). Biochemical changes are considered with histopathomorphologic impairments of aortic endothelium. Treatment with afobazole suppressed free-radical oxidation, increased activity of SOD and concentration of total metabolites of NO and a level of eNOS expression and also restored of a histologic pattern of aortic endothelium due to activation of nucleocytoplasmic regenerative processes.
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Dzugkoev S.G., Kozyrev K.M., Gumanova N.G., Dzugkoeva F.S. (2012) Biomeditsinskaya khimiya, 58(4), 438-445.
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