Molecular forms of adiponectin: comparative evaluation of their correlations with parameters of carbohydrate and lipid metabolism

   
Tanyanskiy D.A.1 , Denisenko A.D.1

1. Research Institute of Experimental Medicine, North-Western Branch of Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20125804457      UDK: 616.37.379-008.64      PubMed Id: 23413690
Year: 2012  Volume: 58  Issue: 4  Pages: 457-466
Interrelationship between total, multimer (MM) and oligomer (OM) adiponectin blood concentrations with some metabolic parameters has been investigated in 49 men and 49 women (mean age of 57.3±10.1 years). We have found negative correlations between total blood adiponectin and its MM form content with body mass index, waist circumference, the insulin resistance index HOMA, with blood concentrations of insulin, glucose, free fatty acids, triglycerides and also positive correlations with high density lipoprotein cholesterol content. There was a poor correlation between OM adiponectin concentration with any parameter studied. According to the regression analysis, concentration of total adiponectin but not its MM form was an independent determinant of the HOMA index in women and free fatty acid concentration in men. In the group of men with the low level of adiponectin its MM form but not total adiponectin reversely correlated with the HOMA index and was its independent determinant. Thus, correlation between blood adiponectin concentration and metabolic parameters is associated with its MM rather than OM form. Study of the role of adiponectin in development of metabolic disorders may be limited to determination of total blood adiponectin concentration except a group of male patients characterized by a low level of this adipokine. In these patients concentrations of the MM form should be determined.
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Tanyanskiy D.A., Denisenko A.D. (2012) Biomeditsinskaya khimiya, 58(4), 457-466.
This paper is also available as the English translation:10.1134/S1990750811030140
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