References Show Archakov A.I., Lisitsa A.V., Petushkova N.A., Karuzina I. I. (2008) Klinicheskaya meditsina, 86(2), 4-8 Scholar google search Archakov A.I. (1975) Microsomal oxidation, Nauka, M. Scholar google search Nelson D.R. (2011) Biochem. Biophys. Acta, 1814, 14-18. CrossRef Scholar google search Kukes V.G., Grachev S.I., Syichev D.A., Ramenskaya G.V. (2008) Metabolizm lekarstvennyih sredstv. Nauchnyie osnovyi personifitsirovannoy meditsinyi, GEOTAR-Media, M Scholar google search Omura T., Sato T. (1964) J. Biol. Chem., 237, 1375-1376. Scholar google search Peisach J., Stern J.O., Blumberd W.E. (1973) Drug Metab. Dispos., 1(1), 45-61. Scholar google search Anderson L., Seilhamer J. (1997) Electrophoresis, 18, 533-537. CrossRef Scholar google search Raunio H., Hakkola J., Hukkanen J., Pelkonen O., Edwards R., Boobis A., Anttila S. (1998) Arch. Toxicol. Suppl., 20, 465-469. CrossRef Scholar google search Luss H., Li R.K., Shapiro R.A., Tzeng E., McGowan F.X., Yoneyama T., Hatakeyama K., Geller D.A., Mickle D.A., Simmons R.L., Billiar T.R. (1997) J. Mol. Cell Cardiol., 29, 1153-1165. CrossRef Scholar google search Pradet-Balade B., Boulme F., Beug H., Mullner E.W., Garcia-Sanz J.A. (2001) Trends Biochem. Sci., 26(4), 225-229. CrossRef Scholar google search Caron E., Rioux N., Olivier N., Lebel-Talbot H., Hamelin B. (2005) J. Biochem. Molecular. Toxicology, 19, 368-378. CrossRef Scholar google search Edwards R.J., Boobis A.R., Davis D.S. (2003) Drug Metab. Dispos., 31, 1470-1480. Scholar google search Kornilayev B.A., Alterman M.A. (2008) Toxicology In Vitro, 22, 779-787. CrossRef Scholar google search Wang M.Z., Wu J.Q., Dennison J.B., Briges A.S., Hall S.D., Kornbluth S., Tidwell R.R., Smith P.C., Voyksner R.D., Paine M.F., Hall J.E. (2008) Proteomics, 8, 4186-4196. CrossRef Scholar google search Walter T., Mann M. (2010) J. Cell Biol., 190, 491-500. CrossRef Scholar google search Galeva N., Alterman M. (2002) Proteomics, 2, 713-722. CrossRef Scholar google search Petushkova N.A., Kanaeva I.P., Lisitsa A.V., Sheremetyeva G.F., Zgoda V.G., Samenkova N.F., Karuzina I.I., Archakov A.I. (2006) Toxicology In Vitro, 20, 966-974. CrossRef Scholar google search Petushkova N.A., Lisitsa A.V. (2012) Methods in molecular biology, 909, 63-82. Scholar google search Sutton C.W., Sutherland M., Shnyder S., Patterson L.H. (2010) Proteomics, 10, 327-331. CrossRef Scholar google search Makino T., Kinoshita J., Arakawa S., Ito K., Ando Y., Yamoto T., Teranishi M., Sanbuissho A., Nakayama H. (2009) J. Toxicol. Sci., 34, 647-661. CrossRef Scholar google search Zgoda V.G., Moshkovskii S.A., Ponomarenko E.A., Andreewski T.V., Kopylov A.T., Tikhonova O.V., Melnik S.A., Lisitsa A.V., Archakov A.I. (2009) Proteomics, 9, 4102-4105. CrossRef Scholar google search Langenfeld E., Meyer H.E., Marcus K. (2008) Anal. Bioanal. Chem., 392, 1123-1134. CrossRef Scholar google search Galeva N., Yakovlev D., Koen Y., Duzhak T., Alterman M. (2003) Drug Metab. Dispos., 31, 351-355. CrossRef Scholar google search Roy L., LaBoissiere S., Abdou E., Thibault G., Hamel N., Taheri M., Boismenu D., Lanoix J., Kearney R.E., Paiement J. (2010) Biochim. Biophys. Acta, 1804, 1869-1881. CrossRef Scholar google search Dail M.B., Shack A., Chambers J.E., Burgess S.C. (2008) Toxicological Sciences, 106(2), 556-569. CrossRef Scholar google search Lee H.J., Kwon M.S., Lee E.Y., Cho S.Y., Paik Y.K. (2008) Proteomics, 8, 2168-2177. CrossRef Scholar google search Nisar S., Lane C.S., Wilderspin A.F., Welham K.J., Griffiths W.J., Patterson L.H. (2004) Drug Metab. Dispos., 32(4), 382-386. CrossRef Scholar google search Kopylov A.T., Zgoda V.G. (2007) Biomeditsinskaya Khimiya, 53(6), 613-643 Scholar google search Bantscheff M., Schirle M., Sweetman G., Rick .J, Kuster B. (2007) Anal. Bioanal. Chem., 389, 1017-1031. Scholar google search Ong S.E., Mann M. (2006) Nature Protocols, 1, 2650-2660. CrossRef Scholar google search Gerber S.A., Rush J., Stemman O., Kirschner M.W., Gugi S.P. (2003) Proc. Natl. Acad. Sci. USA, 100, 6940-6945. CrossRef Scholar google search Ong S.E., Kratchmarova I., Mann M. (2003) J. Proteome Res., 2(2), 173-181. CrossRef Scholar google search Ong S.E., Blagoev B., Kratchmarova I., Kristensen D.B., Steen H., Pandey A., Mann M. (2002) Mol. Cell. Proteomics., 1, 376-386. CrossRef Scholar google search Everley P.A., Krijgsveld J., Zetter B.R., Gygi S.P. (2004) Mol. Cell Proteomics, 3, 729-735. CrossRef Scholar google search Jia N., Liu X., Wen J., Qian L., Qian X., Wu L., Fan G. (2007) Toxicology, 237, 1-11. CrossRef Scholar google search Ji C., Zhang N., Damaraju S., Damaraju V., Carpenter P., Cass C.E., Li L. (2007) Anal. Chim.Acta, 585(2), 219-226. CrossRef Scholar google search Ji C., Guo N., Li L. (2005) J. Proteome Res., 4, 2099-2108. CrossRef Scholar google search Simons B.L., Wang G., Shen R.F., Knepper M.A. (2006) Rapid Commun. Mass Spectrom., 20, 2463-2477. CrossRef Scholar google search Hsu J.L., Huang S.Y., Chow N.H., Chen S.H. (2003) Anal. Chem., 75, 6843-6852. CrossRef Scholar google search Gygi S.P., Rist B., Griffin T.J., Eng J. (2002) J. Proteome Res., 1(1), 47-54. CrossRef Scholar google search Gygi S.P., Rist B., Gerber S.A., Turecek F., Gelb M.H., Aebersold R. (1999) Nat. Biotechnol., 17, 994-999. CrossRef Scholar google search Jenkins R.E., Kitteringham N.R., Hunter C.L., Webb S., Hunt T.J., Elsby R., Watson R.B., Williams D., Pennington S., Park B.K. (2006) Proteomics, 6, 1934-1947. CrossRef Scholar google search Schmidt A., Kellermann J., Lottspeich F. (2005) Proteomics, 5(1), 4-15. CrossRef Scholar google search Ross P.L., Huang Y.N., Marchese J.N., Williamson B., Parker K., Hattan S., Khainovski N., Pillai S., Dey S., Daniels S., Purkayastha S., Juhasz P., Martin S., Bartlet-Jones M., He F., Jacobson A., Pappin D.J. (2004) Mol. Cell Proteomics, 3, 1154-1169. CrossRef Scholar google search Griffin T.J., Xie H., Bandhakavi S., Popko J. Mohan A., Carlis J.V., Higgins L. (2007) J. Proteome Res., 6, 4200-4209. CrossRef Scholar google search Wiese S., Reidegeld K.A., Meyer H.E., Warscheid B. (2007) Proteomics, 7(3), 340-350. CrossRef Scholar google search Heller M., Mattou H., Menzel C., Yao X. (2003) J. Am. Soc. Mass Spectrom., 14(7), 704-718. CrossRef Scholar google search Fenselau C., Yao X. (2007) Methods Mol. Biol., 359, 135-142. CrossRef Scholar google search Ramos-Fernandez A., Lopez-Ferrer D., Vazquez J. (2007) Mol. Cell Proteomics, 6, 1274-1286. CrossRef Scholar google search Lopez-Ferrer D., Ramos-Fernandez A., Martinez-Bartolome S., Garcia-Ruiz P. (2006) Proteomics, 6(1), 4-11. CrossRef Scholar google search Beynon R.J., Doherty M.K., Pratt J.M., Gaskell S.J. (2005) Nature Methods, 2, 587-589. CrossRef Scholar google search Pratt J.M., Simpson D.M., Doherty M.K., Rivers J., Gaskell S.J., Beynon R.J. (2006) Nature Protocols, 1, 1029-1043. CrossRef Scholar google search Rivers J., Simpson D.M., Robertson D.H., Gaskell S.J. (2007) Mol. Cell Proteomics, 6, 1416-1427. CrossRef Scholar google search Brun V., Dupuis A., Adrait A., Marcellin M. (2007) Mol. Cell Proteomics, 6, 2139-2149. CrossRef Scholar google search Yu A.M., Qu J., Felmlee M.A., Cao J., Jiang X.L. (2009) Drug Metab. Dispos., 37(1), 170-177. CrossRef Scholar google search Alterman M.A., Kornilayev B., Duzhak T., Yakovlev D. (2005) Drug Metab. Dispos., 33, 1399-1407. CrossRef Scholar google search Duan X., Chen X., Yang Y., Zhong D. (2007) Rapid. Commun. Mass. Spectrom., 21, 3234-3244. CrossRef Scholar google search Seibert C., Davidson B.R., Fuller B.J., Patterson L.H., Griffiths W.J., Wang Y. (2009) J. Proteome Res., 8, 1672-1681. CrossRef Scholar google search Huang J.H., Tsai M.L., Chen Y.W., Chen S.H. (2001) J. Proteomics, 74, 2734-2744. CrossRef Scholar google search Wang D., Zhang M. (2007) J. Chrom. B, 855, 290-294. CrossRef Scholar google search Lane C., Wang Y., Betts R. (2007) Mol. Cell Proteomics, 6, 953-962. CrossRef Scholar google search Wang Y., Al-Gazzar A., Seibert C., Sharif A., Lane C., Griffiths W.J. (2006) Biochem. Soc. Trans., 34, 1246-1251. CrossRef Scholar google search Langenfeld E., Zanger U.M., Jung K., Meyer H.E., Marcus K. (2009) Proteomics, 9, 2313-2323. CrossRef Scholar google search Kawakami H., Ohtsuki S., Kamiie J., Suzuki T., Abe T., Terasaki T. (2011) J. Pharm. Sci., 100(1), 341-352. CrossRef Scholar google search Zlokarnic G., Grootenhuis P., Watson J. (2005) Drug discovery today, 10, 14440-14450. Scholar google search Rodrigues A.D. Kukulka M.J., Surber B.W., Thomas S.B., Uchic J.T., Rotert G.A., Michel G., Thome-Kromer B., Machinist J.M. (1994) Anal. Biochem., 219, 309-320. CrossRef Scholar google search Delaporte E., Slaughter D.E., Egan M.A., Gatto G.J., Santos A., Shelley J., Price E., Howells L., Dean D.C., Rodrigues A.D. (2001) J. Biomol. Screen., 6(4), 225-231. CrossRef Scholar google search Phillips I., Shephard E. (2006) Cytochrome P450 Protocols, USA, Totowa, New Jersey, Humana Press Inc. Scholar google search Yan Z., Caldwell G. (2007) Methods in Pharmacology and Toxicology. Optimization in Drug Discovery: In Vitro Methods, USA, Totowa, NJ, Humana Press Inc. Scholar google search Stresser D.M., Turner S.D., Blanchard A.P., Miller V.P., Crespi L. (2002) Drug Metab. Dispos., 30, 845-852. CrossRef Scholar google search Di L., Kerns E.H., Li S., Carter G.T. (2007) Intern. J. Pharm., 335, 1-11. CrossRef Scholar google search Petushkova N.A., Lisitsa A.V., Pozdnev V.F., Karuzina I.I. (2010) Biomeditsinskaya Khimiya , 56(1), 132-137 CrossRef Scholar google search Donato M.T., Jimenes N., Castell J., Gomez-Lechon J. (2004) Drug Metab. Dispos., 32(7), 699-706. CrossRef Scholar google search Dixit V., Hariparsad N., Desai P., Unadkat J. (2007) Biopharm. Drug Dispos., 28, 257-262. CrossRef Scholar google search Lahos A., Donato L., Gomez-Lechon J., Castell J. (2007) Toxicology In Vitro, 21, 1247-1252. CrossRef Scholar google search Lin T., Pan K., Mordenti J., Pan L. (2007) J. Pharm. Sci., 96(9), 2485-2493. CrossRef Scholar google search Smith D., Sadagopan N., Zientek M., Reddy A., Cohen L. (2007) J. Chrom. B., 850, 455-463. CrossRef Scholar google search Testino S.A., Patoney G. (2003) J. Pharm. and Biomed. Anal., 30, 1459-1467. CrossRef Scholar google search Li X., Chen X., Li Q., Wang L., Zhong D. (2007) J. Chrom. B., 852, 128-137. CrossRef Scholar google search Walsky R., Obach R. (2004) Drug Metab. Dispos., 32(6), 23-29. CrossRef Scholar google search Yao M., Zhu M., Sinz M., Zhang H., Humphreys W. (2007) J. Pharm. Biomed. Anal., 44, 211-223. CrossRef Scholar google search Zhang T., Zhu Y., Gunaratna C. (2002) J. Chrom. B., 789, 371-379. CrossRef Scholar google search Tolonen A., Turpeinen M., Petsalo A., Uusitalo J., Pelkonen O. (2007) J. Mass Spectrom., 42, 960-966. CrossRef Scholar google search Turpeinen M., Uusitalo J., Jorma J., Pelkonen O. (2005) Eur. J. Pharmac. Sci., 24, 123-132. CrossRef Scholar google search Dierks E., Stams K., Lim H.-K., Cornelius G., Zhang H., Ball S. (2001) Drug Metab. Dispos., 29, 23-29. Scholar google search O`Donnell C., Grime K., Courtney P., Slee D., Riley R.J. (2007) Drug Metab. Dispos., 35(3), 381-385. CrossRef Scholar google search Bhoopathy S., Xin B., Unger S.E., Karnes H.T. (2005) J. Pharm. Biomed. Anal., 37, 739-749. CrossRef Scholar google search Williamson B.L., Purkayastha S., Hunter C.L., Nuwaysir L., Hill J., Easterwood L., Hill J. (2011) Proteomics, 11, 33-41. CrossRef Scholar google search 
