The influence of natural dicarbonils on the antioxidant enzymes activity in vitro and in vivo

Lankin V.Z.1 , Konovalova G.G.1, Tikhaze A.K.1, Nedosugova L.V.1

1. Russian Cardiology Research Complex
Section: Experimental/Clinical Study
DOI: 10.18097/PBMC20125806727      PubMed Id: 23350204
Year: 2012  Volume: 58  Issue: 6  Pages: 727-736
Natural dicarbonyls, which may be accumulated during oxidative stress in atherosclerosis (e.g. malondialdehyde) or carbonyl stress in diabetes mellitus (glyoxal and methylglyoxal) effectively inhibited the activities of commercial preparations of antioxidant enzymes: catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and Se-contained glutathione peroxidase from human and bovine erythrocytes and also rat liver glutathione-S-transferase. After incubation of human erythrocytes with 10 mM of each investigated dicarbonyls the decrease of intracellular Cu,Zn-SOD was observed. The decreased activity of erythrocyte Cu,Zn-SOD was also detected in diabetic patients with carbohydrate metabolism disturbance but effective sugar-lowered therapy was accompanied by the increase of this enzyme activity. The increase of erythrocytes activity of Cu,Zn-SOD of diabetic patients theated with metformin (which may utilize methylglyoxal) was higher than in erythrocytase of diabetic patients subjected to traditional therapy.
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Keywords: free radical oxidation, malondialdehyde, glyoxal, methylglyoxal, antioxidant enzymes, Cu,Zn-superoxide dismutase, metformin

Lankin, V. Z., Konovalova, G. G., Tikhaze, A. K., Nedosugova, L. V. (2012). The influence of natural dicarbonils on the antioxidant enzymes activity in vitro and in vivo. Biomeditsinskaya Khimiya, 58(6), 727-736.
This paper is also available as the English translation: 10.1134/S1990750812010106
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