Comparative studies on the genotoxic activity of a new palladium (II) acidocomplex vs cisplatin in human blood lymphocytes

   
Grekhova A.K.1 , Gorbacheva L.B.1, Ivanova N.A.2, Efimenko I.A.2, Osipov A.N.3

1. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
2. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
3. Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135901107      UDK: 61:615.28:612.42      PubMed Id: 23650729
Year: 2013  Volume: 59  Issue: 1  Pages: 107-114
A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH] [PdCl ] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited biphasic dose-effect relationship: a linear decrease in the DNA percent in the comet tail and the region of the "plateau". However, in the "plateau" region, morfozol reduced the DNA percent in the comet tail up to 6 times while cisplatin caused a 2-fold decrease only. Morfozol, like cisplatin, inducing DNA-protein cross-linking and generating reactive oxygen species, was more effective than cisplatin.
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Grekhova A.K., Gorbacheva L.B., Ivanova N.A., Efimenko I.A., Osipov A.N. (2013) Biomeditsinskaya khimiya, 59(1), 107-114.
This paper is also available as the English translation:10.1134/S1990750813030050
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