Influence of ethanol-metabolising systems on intensity of lipid peroxidation processes in gastrointestinal tract of rats

   
Petushok N.E.1 , Grohovskaya T.Ch.2, Melnichenko N.G.2, Pronko S.P.1

1. State Medical University
2. Institute of Pharmacology and Biochemistry, National Academy of Sciences of Belarus
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135901076      UDK: 577.16:591.133.1      PubMed Id: 23650724
Year: 2013  Volume: 59  Issue: 1  Pages: 76-80
The effects of some ethanol-metabolising systems (aldehyde dehydrogenase, catalase, cytochrome P450 2E1) on activation of lipid peroxidation (LPO) processes in gastrointestinal tract of rats have been studied using inhibitors of these systems. The intensity of LPO processes was evaluated by thiobarbituric acid-reactive products and chemiluminiscence intensity. It was found, that the acetadehyde metabolism play the main role in the indiction of lipid peroxidation in the gastrointestinal tract of rats.
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Petushok N.E., Grohovskaya T.Ch., Melnichenko N.G., Pronko S.P. (2013) Biomeditsinskaya khimiya, 59(1), 76-80.
This paper is also available as the English translation:10.1134/S1990750812020084
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