The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct

   
Zverinsky I.V.1 , Melnichenko N.G.1, Poplavsky V.A.1, Sutko I.P.1, Telegin P.G.1, Shlyahtun A.G.1

1. Institute of Pharmacology and Biochemistry, National Academy of Sciences of Belarus
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135901090      PubMed Id: 23650726
Year: 2013  Volume: 59  Issue: 1  Pages: 90-96
On the eighth day after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injection of berberine (10 mg/kg) for 6 days caused a partial normalization of permeability of hepatocytes plasma membranes and activity of microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. Membrane-stabilizing effect of berberine is probably realized at the level of inhibition of prooxidant status of liver cells.
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Keywords: Cholestasis, berberine, cytochrome P450, flavin-containing monooxygenases
Citation:

Zverinsky, I. V., Melnichenko, N. G., Poplavsky, V. A., Sutko, I. P., Telegin, P. G., Shlyahtun, A. G. (2013). The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct. Biomeditsinskaya khimiya, 59(1), 90-96.
This paper is also available as the English translation: 10.1134/S1990750812020163
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